ZMYND8 preferentially binds phosphorylated EZH2 to promote a PRC2-dependent to -independent function switch in hypoxia-inducible factor–activated cancer

Both gene repressor (Polycomb-dependent) and activator (Polycomb-independent) functions of the Polycomb protein enhancer of zeste homolog 2 (EZH2) are implicated in cancer progression. EZH2 protein can be phosphorylated at various residues, such as threonine 487 (T487), by CDK1 kinase, and such phos...

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Detalles Bibliográficos
Autores principales: Tang, Bo, Sun, Rui, Wang, Dejie, Sheng, Haoyue, Wei, Ting, Wang, Liguo, Zhang, Jun, Ho, Thai H., Yang, Lu, Wei, Qiang, Huang, Haojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923384/
https://www.ncbi.nlm.nih.gov/pubmed/33593912
http://dx.doi.org/10.1073/pnas.2019052118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923384/
https://www.ncbi.nlm.nih.gov/pubmed/33593912
http://dx.doi.org/10.1073/pnas.2019052118

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