Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex

The Shieldin complex, composed of REV7, SHLD1, SHLD2, and SHLD3, protects DNA double-strand breaks (DSBs) to promote nonhomologous end joining. The AAA(+) ATPase TRIP13 remodels Shieldin to regulate DNA repair pathway choice. Here we report crystal structures of human SHLD3–REV7 binary and fused SHL...

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Detalles Bibliográficos
Autores principales: Xie, Wei, Wang, Shengliu, Wang, Juncheng, de la Cruz, M. Jason, Xu, Guotai, Scaltriti, Maurizio, Patel, Dinshaw J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923543/
https://www.ncbi.nlm.nih.gov/pubmed/33597306
http://dx.doi.org/10.1073/pnas.2024512118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923543/
https://www.ncbi.nlm.nih.gov/pubmed/33597306
http://dx.doi.org/10.1073/pnas.2024512118

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