mTORC1 activity is supported by spatial association with focal adhesions

The mammalian target of rapamycin complex 1 (mTORC1) integrates mitogenic and stress signals to control growth and metabolism. Activation of mTORC1 by amino acids and growth factors involves recruitment of the complex to the lysosomal membrane and is further supported by lysosome distribution to the...

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Detalles Bibliográficos
Autores principales: Rabanal-Ruiz, Yoana, Byron, Adam, Wirth, Alexander, Madsen, Ralitsa, Sedlackova, Lucia, Hewitt, Graeme, Nelson, Glyn, Stingele, Julian, Wills, Jimi C., Zhang, Tong, Zeug, André, Fässler, Reinhard, Vanhaesebroeck, Bart, Maddocks, Oliver D.K., Ponimaskin, Evgeni, Carroll, Bernadette, Korolchuk, Viktor I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923692/
https://www.ncbi.nlm.nih.gov/pubmed/33635313
http://dx.doi.org/10.1083/jcb.202004010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923692/
https://www.ncbi.nlm.nih.gov/pubmed/33635313
http://dx.doi.org/10.1083/jcb.202004010

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