xCT-Driven Expression of GPX4 Determines Sensitivity of Breast Cancer Cells to Ferroptosis Inducers

Inducers of ferroptosis such as the glutathione depleting agent Erastin and the GPX4 inhibitor Rsl-3 are being actively explored as potential therapeutics in various cancers, but the factors that determine their sensitivity are poorly understood. Here, we show that expression levels of both subunits...

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Detalles Bibliográficos
Autores principales: Lee, Namgyu, Carlisle, Anne E., Peppers, Austin, Park, Sung Jin, Doshi, Mihir B., Spears, Meghan E., Kim, Dohoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923775/
https://www.ncbi.nlm.nih.gov/pubmed/33672555
http://dx.doi.org/10.3390/antiox10020317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923775/
https://www.ncbi.nlm.nih.gov/pubmed/33672555
http://dx.doi.org/10.3390/antiox10020317

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