Tacrine-Coumarin Derivatives as Topoisomerase Inhibitors with Antitumor Effects on A549 Human Lung Carcinoma Cancer Cell Lines

A549 human lung carcinoma cell lines were treated with a series of new drugs with both tacrine and coumarin pharmacophores (derivatives 1a–2c) in order to test the compounds’ ability to inhibit both cancer cell growth and topoisomerase I and II activity. The ability of human topoisomerase I (hTOPI)...

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Detalles Bibliográficos
Autores principales: Konkoľová, Eva, Hudáčová, Monika, Hamuľaková, Slávka, Jendželovský, Rastislav, Vargová, Jana, Ševc, Juraj, Fedoročko, Peter, Kožurková, Mária
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924348/
https://www.ncbi.nlm.nih.gov/pubmed/33672694
http://dx.doi.org/10.3390/molecules26041133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924348/
https://www.ncbi.nlm.nih.gov/pubmed/33672694
http://dx.doi.org/10.3390/molecules26041133

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