Functional Characterization of Antithrombin Mutations by Monitoring of Thrombin Inhibition Kinetics

Inactivation of thrombin by the endogenous inhibitor antithrombin (AT) is a central mechanism in the regulation of hemostasis. This makes hereditary AT deficiency, which is caused by SERPINC1 gene mutations, a major thrombophilic risk factor. Aim of this study was to assess to what extent AT mutatio...

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Detalles Bibliográficos
Autores principales: Reda, Sara, Müller, Jens, Pavlova, Anna, Pezeshkpoor, Behnaz, Oldenburg, Johannes, Pötzsch, Bernd, Rühl, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924598/
https://www.ncbi.nlm.nih.gov/pubmed/33672736
http://dx.doi.org/10.3390/ijms22042119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924598/
https://www.ncbi.nlm.nih.gov/pubmed/33672736
http://dx.doi.org/10.3390/ijms22042119

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