Cargando…

Functional Characterization of Antithrombin Mutations by Monitoring of Thrombin Inhibition Kinetics

Inactivation of thrombin by the endogenous inhibitor antithrombin (AT) is a central mechanism in the regulation of hemostasis. This makes hereditary AT deficiency, which is caused by SERPINC1 gene mutations, a major thrombophilic risk factor. Aim of this study was to assess to what extent AT mutatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reda, Sara, Müller, Jens, Pavlova, Anna, Pezeshkpoor, Behnaz, Oldenburg, Johannes, Pötzsch, Bernd, Rühl, Heiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924598/ https://www.ncbi.nlm.nih.gov/pubmed/33672736 http://dx.doi.org/10.3390/ijms22042119

Ejemplares similares

PC Deficiency Testing: Thrombin-Thrombomodulin as PC Activator and Aptamer-Based Enzyme Capturing Increase Diagnostic Accuracy
por: Reda, Sara, et al.
Publicado: (2021)

Activated Factor XI is Increased in Plasma in Response to Surgical Trauma but not to Recombinant Activated FVII-Induced Thrombin Formation
por: Rühl, Heiko, et al.
Publicado: (2022)

Functional lupus anticoagulant testing in a large retrospective cohort of thrombosis patients with direct oral anticoagulants
por: Reda, Sara, et al.
Publicado: (2020)

Impaired in vivo activated protein C response rates indicate a thrombophilic phenotype in inherited thrombophilia
por: Reda, Sara, et al.
Publicado: (2022)

Label-Free Kinetic Studies of Hemostasis-Related Biomarkers Including D-Dimer Using Autologous Serum Transfusion
por: Rühl, Heiko, et al.
Publicado: (2015)

Variation in Plasma Levels of Apixaban and Rivaroxaban in Clinical Routine Treatment of Venous Thromboembolism
por: Reda, Sara, et al.
Publicado: (2022)

Increased Prevalence of Elevated D-Dimer Levels in Patients on Direct Oral Anticoagulants: Results of a Large Retrospective Study
por: Reda, Sara, et al.
Publicado: (2022)

Insights into the Molecular Genetic of Hemophilia A and Hemophilia B: The Relevance of Genetic Testing in Routine Clinical Practice
por: Pezeshkpoor, Behnaz, et al.
Publicado: (2022)

Assay for ADAMTS-13 Activity with Flow Cytometric Readout
por: Müller, Jens, et al.
Publicado: (2022)

An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII
por: Pezeshkpoor, Behnaz, et al.
Publicado: (2017)

Early Changes in the Antithrombin and Thrombin-Antithrombin Complex in Patients With Paroxysmal Atrial Fibrillation
por: Negreva, Mariya, et al.
Publicado: (2016)

Impact of Hormone-Associated Resistance to Activated Protein C on the Thrombotic Potential of Oral Contraceptives: A Prospective Observational Study
por: Rühl, Heiko, et al.
Publicado: (2014)

Aptamer loaded superparamagnetic beads for selective capturing and gentle release of activated protein C
por: Hamedani, Nasim Shahidi, et al.
Publicado: (2022)

Comparison of antithrombin‐dependent and direct inhibitors of factor Xa or thrombin on the kinetics and qualitative characteristics of blood clots
por: Salta, Stella, et al.
Publicado: (2018)

Activity Pattern Analysis Indicates Increased but Balanced Systemic Coagulation Activity in Response to Surgical Trauma
por: Friedrich, Max Julian, et al.
Publicado: (2018)

Optimization and evaluation of a two-stage chromogenic assay procedure for measurement of emicizumab plasma levels
por: Hamedani, Nasim Shahidi, et al.
Publicado: (2022)

Thrombin antithrombin complex and IL-18 serum levels in stroke patients
por: Piazza, Ornella, et al.
Publicado: (2010)

Plasma levels of thrombin and activated protein C in patients with acute myocardial Infarction: An observational study
por: Becher, Tobias, et al.
Publicado: (2022)

Familial Multiple Coagulation Factor Deficiencies (FMCFDs) in a Large Cohort of Patients—A Single-Center Experience in Genetic Diagnosis
por: Preisler, Barbara, et al.
Publicado: (2021)

F8 Inversions at Xq28 Causing Hemophilia A Are Associated With Specific Methylation Changes: Implication for Molecular Epigenetic Diagnosis
por: Jamil, Muhammad Ahmer, et al.
Publicado: (2019)

Thrombin Generation Decrease After LMWH Administration in an Antithrombin-Deficient Pregnant Woman With a Homozygous HBS II Mutation
por: Malikova, Ivana, et al.
Publicado: (2023)

Elevated Microparticles, Thrombin-antithrombin and VEGF Levels in Colorectal Cancer Patients Undergoing Chemotherapy
por: Wojtukiewicz, Marek Z., et al.
Publicado: (2020)

Tailoring the effect of antithrombin-targeting therapy in haemophilia A using in silico thrombin generation
por: de Laat-Kremers, Romy M. W., et al.
Publicado: (2021)

Thrombin generation capacity is enhanced by low antithrombin activity and depends on the activity of the related coagulation factors
por: Tsuchida, Takumi, et al.
Publicado: (2022)

Effect of plasma thrombin-antithrombin complex on ischemic stroke: a systematic review and meta-analysis
por: Song, Peipei, et al.
Publicado: (2023)

Thrombin Decrease in Thrombin Generation after Heparin Administration in a Homozygous Type II Heparin-Binding Site Antithrombin-Deficient Pregnant Woman
por: Malíková, Ivana, et al.
Publicado: (2023)

Genetic Analysis of a Pedigree With Antithrombin and Prothrombin Compound Mutations and Antithrombin Heterozygotes
por: Zhang, Haiyue, et al.
Publicado: (2022)

Functional and Structural Characterization of Nucleic Acid Ligands That Bind to Activated Coagulation Factor XIII
por: Hamedani, Nasim Shahidi, et al.
Publicado: (2021)

On the Specificity of Heparin/Heparan Sulfate Binding to Proteins. Anion-Binding Sites on Antithrombin and Thrombin Are Fundamentally Different
por: Mosier, Philip D., et al.
Publicado: (2012)

Plasma centrifugation does not influence thrombin-antithrombin and plasmin-antiplasmin levels but determines platelet microparticles count
por: Stępień, Ewa, et al.
Publicado: (2015)

Increased perihematomal neuron autophagy and plasma thrombin–antithrombin levels in patients with intracerebral hemorrhage: An observational study
por: Wu, Chenghan, et al.
Publicado: (2019)

Further Evidence That MicroRNAs Can Play a Role in Hemophilia A Disease Manifestation: F8 Gene Downregulation by miR-19b-3p and miR-186-5p
por: Jankowska, Katarzyna I., et al.
Publicado: (2020)

Identification and characterization of two SERPINC1 mutations causing congenital antithrombin deficiency
por: Wang, Han-lu, et al.
Publicado: (2023)

Analysis of blood coagulation in mice: pre-analytical conditions and evaluation of a home-made assay for thrombin-antithrombin complexes
por: Sommeijer, Dirkje W, et al.
Publicado: (2005)

Thrombin-antithrombin complex measurement using a point-of-care testing device for diagnosis of disseminated intravascular coagulation in dogs
por: Rimpo, Kenji, et al.
Publicado: (2018)

Performance evaluation of thrombomodulin, thrombin‐antithrombin complex, plasmin‐α2‐antiplasmin complex, and t‐PA: PAI‐1 complex
por: Chen, Qian, et al.
Publicado: (2019)

Antithrombin‐III mitigates thrombin‐mediated endothelial cell contraction and sickle red blood cell adhesion in microscale flow
por: Wulftange, William J., et al.
Publicado: (2022)

Clinical controversies in anticoagulation monitoring and antithrombin supplementation for ECMO
por: Chlebowski, Meghan M., et al.
Publicado: (2020)

Analysis of the influence of antithrombin on microvascular thrombosis: anti-inflammation is crucial for anticoagulation
por: Sorg, Heiko, et al.
Publicado: (2015)

Thrombin antithrombin complex concentration as an early predictor of deep vein thrombosis after total hip arthroplasty and total knee arthroplasty
por: Lin, Zhencan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sjj9bkehhesag4loohjjju6gog