TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption

Toll-like receptor 7 (TLR7) agonist and PGT121 (broadly neutralizing antibody, bnAb) administration previously delayed viral rebound and induced SHIV remission. We evaluated the impact of GS-986 (TLR7 agonist) and dual bnAbs on viral rebound after antiretroviral therapy (ART) interruption. Rhesus ma...

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Detalles Bibliográficos
Autores principales: Hsu, Denise C., Schuetz, Alexandra, Imerbsin, Rawiwan, Silsorn, Decha, Pegu, Amarendra, Inthawong, Dutsadee, Sopanaporn, Jumpol, Visudhiphan, Pornsuk, Chuenarom, Weerawan, Keawboon, Boot, Shi, Wei, Robb, Merlin L., Mascola, John R., Geleziunas, Romas, Koup, Richard A., Barouch, Dan H., Michael, Nelson L., Vasan, Sandhya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924766/
https://www.ncbi.nlm.nih.gov/pubmed/33600506
http://dx.doi.org/10.1371/journal.ppat.1009339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924766/
https://www.ncbi.nlm.nih.gov/pubmed/33600506
http://dx.doi.org/10.1371/journal.ppat.1009339

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