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In Silico Simulation of the Systemic Drug Exposure Following the Topical Application of Opioid Analgesics in Patients with Cutaneous Lesions

The use of opioid analgesics in treating severe pain is frequently associated with putative adverse effects in humans. Topical agents that are shown to have high efficacy with a favorable safety profile in clinical settings are great alternatives for pain management of multimodal analgesia. However,...

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Detalles Bibliográficos
Autores principales: Khotimchenko, Maksim, Antontsev, Victor, Chakravarty, Kaushik, Hou, Hypatia, Varshney, Jyotika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924840/
https://www.ncbi.nlm.nih.gov/pubmed/33669957
http://dx.doi.org/10.3390/pharmaceutics13020284