Cargando…

Influence of dapivirine vaginal ring use on cervicovaginal immunity and functional microbiome in adolescent girls

OBJECTIVE: The antiretroviral-based dapivirine vaginal ring reduced HIV risk among women in phase III clinical trials. However, limited data exists on the impact of dapivirine on the vaginal microenvironment in adolescents. DESIGN: A comprehensive metaproteomics approach was used to assess host prot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Farr Zuend, Christina, Noël-Romas, Laura, Hoger, Sarah, McCorriser, Stuart, Westmacott, Garrett, Marrazzo, Jeanne, Hillier, Sharon L., Dezzutti, Charlene, Squires, Kathleen, Bunge, Katherine E., Burgener, Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2021
Materias:	Basic Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924934/ https://www.ncbi.nlm.nih.gov/pubmed/33181534 http://dx.doi.org/10.1097/QAD.0000000000002751

Ejemplares similares

Pregnancy associates with alterations to the host and microbial proteome in vaginal mucosa
por: Farr Zuend, Christina, et al.
Publicado: (2020)

Vaginal microbiome-hormonal contraceptive interactions associate with the mucosal proteome and HIV acquisition
por: Noël-Romas, Laura, et al.
Publicado: (2020)

Non-Lactobacillus-Dominant and Polymicrobial Vaginal Microbiomes Are More Common in Younger South African Women and Predictive of Increased Risk of Human Immunodeficiency Virus Acquisition
por: Wang, Yiran, et al.
Publicado: (2022)

Increased Dapivirine Tissue Accumulation through Vaginal Film Codelivery of Dapivirine and Tenofovir
por: Akil, Ayman, et al.
Publicado: (2014)

Pharmacodynamic correlations using fresh and cryopreserved tissue following use of vaginal rings containing dapivirine and/or maraviroc in a randomized, placebo controlled trial
por: Dezzutti, Charlene S., et al.
Publicado: (2016)

Acceptability of the Dapivirine Vaginal Ring in Postmenopausal US Women
por: Shapley-Quinn, Mary Kate, et al.
Publicado: (2022)

Phase 1 pharmacokinetics and safety study of extended duration dapivirine vaginal rings in the United States
por: Liu, Albert Y, et al.
Publicado: (2021)

Greater dapivirine release from the dapivirine vaginal ring is correlated with lower risk of HIV‐1 acquisition: a secondary analysis from a randomized, placebo‐controlled trial
por: Brown, Elizabeth R, et al.
Publicado: (2020)

Physiologically‐based pharmacokinetic model of vaginally administered dapivirine ring and film formulations
por: Kay, Katherine, et al.
Publicado: (2018)

Assessment of risk compensation following use of the dapivirine vaginal ring in southwestern Uganda
por: Kusemererwa, Sylvia, et al.
Publicado: (2022)

Adolescent Girls and Young Women’s Experiences with Disclosing Oral PrEP or Dapivirine Vaginal Ring Use: a Multi-Country Qualitative Analysis
por: Young, Alinda M., et al.
Publicado: (2023)

Dapivirine Bioadhesive Vaginal Tablets Based on Natural Polymers for the Prevention of Sexual Transmission of HIV
por: Cazorla-Luna, Raúl, et al.
Publicado: (2019)

Rational Design of a Multipurpose Bioadhesive Vaginal Film for Co-Delivery of Dapivirine and Levonorgestrel
por: Li, Jing, et al.
Publicado: (2019)

Dapivirine vaginal ring for HIV prevention: modelling health outcomes, drug resistance and cost‐effectiveness
por: Glaubius, Robert, et al.
Publicado: (2019)

Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel
por: Dallal Bashi, Yahya H., et al.
Publicado: (2021)

Acute Infection and Subsequent Subclinical Reactivation of Herpes Simplex Virus 2 after Vaginal Inoculation of Rhesus Macaques
por: Lo, Ming, et al.
Publicado: (2019)

Characteristics of Women Enrolled into a Randomized Clinical Trial of Dapivirine Vaginal Ring for HIV-1 Prevention
por: Palanee-Phillips, Thesla, et al.
Publicado: (2015)

Evaluating the potential impact and cost-effectiveness of dapivirine vaginal ring pre-exposure prophylaxis for HIV prevention
por: Reidy, Meghan, et al.
Publicado: (2019)

Acceptability of the Dapivirine Vaginal Ring for HIV-1 Prevention and Association with Adherence in a Phase III Trial
por: Mayo, Ashley J., et al.
Publicado: (2021)

Refining the in vitro release test method for a dapivirine-releasing vaginal ring to match in vivo performance
por: Murphy, Diarmaid J., et al.
Publicado: (2021)

Increased genital mucosal cytokines in Canadian women associate with higher antigen-presenting cells, inflammatory metabolites, epithelial barrier disruption, and the depletion of L. crispatus
por: Farr Zuend, Christina, et al.
Publicado: (2023)

Association of HPV infection and clearance with cervicovaginal immunology and the vaginal microbiota
por: Shannon, B, et al.
Publicado: (2017)

Cervicovaginal Müllerian papilloma malignant transformation in a prepubertal girl
por: Zou, Juan, et al.
Publicado: (2019)

Impact of Partner-Related Social Harms on Women's Adherence to the Dapivirine Vaginal Ring During a Phase III Trial
por: Palanee-Phillips, Thesla, et al.
Publicado: (2018)

Introducing the Dapivirine Vaginal Ring in Sub-Saharan Africa: What Can We Learn from Oral PrEP?
por: Bhavaraju, Neeraja, et al.
Publicado: (2021)

Safety, Acceptability and Adherence of Dapivirine Vaginal Ring in a Microbicide Clinical Trial Conducted in Multiple Countries in Sub-Saharan Africa
por: Nel, Annalene, et al.
Publicado: (2016)

In vitro drug release, mechanical performance and stability testing of a custom silicone elastomer vaginal ring releasing dapivirine and levonorgestrel
por: Murphy, Diarmaid J., et al.
Publicado: (2022)

Cervicovaginal mucus barrier properties during pregnancy are impacted by the vaginal microbiome
por: Zierden, Hannah C., et al.
Publicado: (2023)

A Caulobacter crescentus Microbicide Protects from Vaginal Infection with HIV-1(JR-CSF) in Humanized Bone Marrow-Liver-Thymus Mice
por: Farr Zuend, Christina, et al.
Publicado: (2019)

Design of Poly(lactic-co-glycolic Acid) (PLGA) Nanoparticles for Vaginal Co-Delivery of Griffithsin and Dapivirine and Their Synergistic Effect for HIV Prophylaxis
por: Yang, Haitao, et al.
Publicado: (2019)

IgG in cervicovaginal mucus traps HSV and prevents vaginal Herpes infections
por: Wang, Ying-Ying, et al.
Publicado: (2014)

Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression
por: Delgado-Diaz, David Jose, et al.
Publicado: (2022)

Probiotics Reduce Vaginal Candidiasis in Pregnant Women via Modulating Abundance of Candida and Lactobacillus in Vaginal and Cervicovaginal Regions
por: Ang, Xin Yee, et al.
Publicado: (2022)

An updated review on the effects of depot medroxyprogesterone acetate on the mucosal biology of the female genital tract
por: Ayele, Hossaena, et al.
Publicado: (2021)

Multiple dosage forms of the NNRTI microbicide dapivirine: product development and evaluation
por: Romano, Joseph
Publicado: (2006)

Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma
por: Liu, Weiwen, et al.
Publicado: (2018)

Transport and Permeation Properties of Dapivirine: Understanding Potential Drug-Drug Interactions
por: Zheng, Ruohui, et al.
Publicado: (2022)

The Interplay Between Cervicovaginal Microbial Dysbiosis and Cervicovaginal Immunity
por: Wang, Ya, et al.
Publicado: (2022)

Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli
por: O'Hanlon, Deirdre E, et al.
Publicado: (2010)

Protease activities of vaginal Porphyromonas species disrupt coagulation and extracellular matrix in the cervicovaginal niche
por: Lithgow, Karen V., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qkeeil2uchh1tgb0a8qd28ulg3