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Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces

During metaphase, chromosome position at the spindle equator is regulated by the forces exerted by kinetochore microtubules and polar ejection forces. However, the role of forces arising from mechanical coupling of sister kinetochore fibers with bridging fibers in chromosome alignment is unknown. He...

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Detalles Bibliográficos
Autores principales: Jagrić, Mihaela, Risteski, Patrik, Martinčić, Jelena, Milas, Ana, Tolić, Iva M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924949/
https://www.ncbi.nlm.nih.gov/pubmed/33480356
http://dx.doi.org/10.7554/eLife.61170