A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

The canonical Wnt pathway transcriptional co-activator β-catenin regulates self-renewal and differentiation of mammalian nephron progenitor cells (NPCs). We modulated β-catenin levels in NPC cultures using the GSK3 inhibitor CHIR99021 (CHIR) to examine opposing developmental actions of β-catenin. Lo...

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Detalles Bibliográficos
Autores principales: Guo, Qiuyu, Kim, Albert, Li, Bin, Ransick, Andrew, Bugacov, Helena, Chen, Xi, Lindström, Nils, Brown, Aaron, Oxburgh, Leif, Ren, Bing, McMahon, Andrew P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924951/
https://www.ncbi.nlm.nih.gov/pubmed/33587034
http://dx.doi.org/10.7554/eLife.64444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924951/
https://www.ncbi.nlm.nih.gov/pubmed/33587034
http://dx.doi.org/10.7554/eLife.64444

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