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Emergence and propagation of epistasis in metabolic networks

Epistasis is often used to probe functional relationships between genes, and it plays an important role in evolution. However, we lack theory to understand how functional relationships at the molecular level translate into epistasis at the level of whole-organism phenotypes, such as fitness. Here, I...

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Detalles Bibliográficos
Autor principal: Kryazhimskiy, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924954/
https://www.ncbi.nlm.nih.gov/pubmed/33527897
http://dx.doi.org/10.7554/eLife.60200