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Acupuncture for Chronic Pain-Related Depression: A Systematic Review and Meta-Analysis
OBJECTIVE: The aim of this systematic review was to summarize and evaluate the existing evidence on the effectiveness and safety of acupuncture in relieving chronic pain-related depression (CPRD). METHODS: We searched seven online databases to identify eligible randomized controlled trials (RCTs) of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925064/ https://www.ncbi.nlm.nih.gov/pubmed/33680223 http://dx.doi.org/10.1155/2021/6617075 |
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author | You, Jianyu Li, Haiyan Xie, Dingyi Chen, Rixin Chen, Mingren |
author_facet | You, Jianyu Li, Haiyan Xie, Dingyi Chen, Rixin Chen, Mingren |
author_sort | You, Jianyu |
collection | PubMed |
description | OBJECTIVE: The aim of this systematic review was to summarize and evaluate the existing evidence on the effectiveness and safety of acupuncture in relieving chronic pain-related depression (CPRD). METHODS: We searched seven online databases to identify eligible randomized controlled trials (RCTs) of acupuncture for CPRD published before September 2020. We included studies that used acupuncture as the intervention group, with or without a control group, and the control group was treated with conventional drugs. Meta-analysis was performed using RevMan 5.3 software. For outcomes, assessments were performed using the Hamilton Depression Scale (HAMD), Visual Analogue Scale (VAS), and adverse events. RESULTS: Eight studies involving 636 participants were identified and included in the meta-analysis. The results showed that single acupuncture treatment and drug treatment have the same effect in improving the HAMD score (MD = −0.14, 95% CI = [−0.88, 0.59], P = 0.71) and alleviating the VAS score (MD = −0.42, 95% CI = [−1.10, −0.27], P = 0.23), but acupuncture treatment is safer (OR = 0.03, 95% CI = [0.01, 0.21], P = 0.0003). In addition, acupuncture combined with drugs (control group) is more beneficial than single-drug treatment in improving the HAMD score (MD = −2.95, 95% CI = [−3.55, −2.36], P < 0.00001) and alleviating the VAS score (MD = −1.06, 95% CI = [−1.65, −0.47], P = 0.0004). CONCLUSION: Acupuncture is an effective and safe treatment for CPRD, and acupuncture combined with drug therapy is more effective than single-drug therapy. Nevertheless, the conclusions were limited due to the low quality and a small number of included studies. |
format | Online Article Text |
id | pubmed-7925064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-79250642021-03-04 Acupuncture for Chronic Pain-Related Depression: A Systematic Review and Meta-Analysis You, Jianyu Li, Haiyan Xie, Dingyi Chen, Rixin Chen, Mingren Pain Res Manag Review Article OBJECTIVE: The aim of this systematic review was to summarize and evaluate the existing evidence on the effectiveness and safety of acupuncture in relieving chronic pain-related depression (CPRD). METHODS: We searched seven online databases to identify eligible randomized controlled trials (RCTs) of acupuncture for CPRD published before September 2020. We included studies that used acupuncture as the intervention group, with or without a control group, and the control group was treated with conventional drugs. Meta-analysis was performed using RevMan 5.3 software. For outcomes, assessments were performed using the Hamilton Depression Scale (HAMD), Visual Analogue Scale (VAS), and adverse events. RESULTS: Eight studies involving 636 participants were identified and included in the meta-analysis. The results showed that single acupuncture treatment and drug treatment have the same effect in improving the HAMD score (MD = −0.14, 95% CI = [−0.88, 0.59], P = 0.71) and alleviating the VAS score (MD = −0.42, 95% CI = [−1.10, −0.27], P = 0.23), but acupuncture treatment is safer (OR = 0.03, 95% CI = [0.01, 0.21], P = 0.0003). In addition, acupuncture combined with drugs (control group) is more beneficial than single-drug treatment in improving the HAMD score (MD = −2.95, 95% CI = [−3.55, −2.36], P < 0.00001) and alleviating the VAS score (MD = −1.06, 95% CI = [−1.65, −0.47], P = 0.0004). CONCLUSION: Acupuncture is an effective and safe treatment for CPRD, and acupuncture combined with drug therapy is more effective than single-drug therapy. Nevertheless, the conclusions were limited due to the low quality and a small number of included studies. Hindawi 2021-02-22 /pmc/articles/PMC7925064/ /pubmed/33680223 http://dx.doi.org/10.1155/2021/6617075 Text en Copyright © 2021 Jianyu You et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article You, Jianyu Li, Haiyan Xie, Dingyi Chen, Rixin Chen, Mingren Acupuncture for Chronic Pain-Related Depression: A Systematic Review and Meta-Analysis |
title | Acupuncture for Chronic Pain-Related Depression: A Systematic Review and Meta-Analysis |
title_full | Acupuncture for Chronic Pain-Related Depression: A Systematic Review and Meta-Analysis |
title_fullStr | Acupuncture for Chronic Pain-Related Depression: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Acupuncture for Chronic Pain-Related Depression: A Systematic Review and Meta-Analysis |
title_short | Acupuncture for Chronic Pain-Related Depression: A Systematic Review and Meta-Analysis |
title_sort | acupuncture for chronic pain-related depression: a systematic review and meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925064/ https://www.ncbi.nlm.nih.gov/pubmed/33680223 http://dx.doi.org/10.1155/2021/6617075 |
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