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De Novo Cholesterol Biosynthesis and Its Trafficking in LAMP-1-Positive Vesicles Are Involved in Replication and Spread of Marek’s Disease Virus

Marek’s disease virus (MDV) transforms CD4(+) T cells and causes a deadly neoplastic disease that is associated with metabolic dysregulation leading to atherosclerosis in chickens. While MDV-infected chickens have normal serum concentrations of cholesterol, their aortic tissues were found to have el...

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Detalles Bibliográficos
Autores principales: Boodhoo, Nitish, Kamble, Nitin, Behboudi, Shahriar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925193/
https://www.ncbi.nlm.nih.gov/pubmed/32999035
http://dx.doi.org/10.1128/JVI.01001-20