Enhanced Ohmyungsamycin A Production via Adenylation Domain Engineering and Optimization of Culture Conditions

Ohmyungsamycins (OMSs) A and B are cyclic depsipeptides produced by marine Streptomyces strains, which are synthesized by a non-ribosomal peptide synthetase. Notably, OMS A exhibits more potent activity against Mycobacterium tuberculosis and human cancer cells than OMS B. The substrate promiscuous a...

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Detalles Bibliográficos
Autores principales: Kim, Eunji, Du, Young Eun, Ban, Yeon Hee, Shin, Yern-Hyerk, Oh, Dong-Chan, Yoon, Yeo Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925391/
https://www.ncbi.nlm.nih.gov/pubmed/33679647
http://dx.doi.org/10.3389/fmicb.2021.626881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925391/
https://www.ncbi.nlm.nih.gov/pubmed/33679647
http://dx.doi.org/10.3389/fmicb.2021.626881

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