Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson’s disease

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of late-onset, familial Parkinson’s disease (PD), and LRRK2 variants are associated with increased risk for sporadic PD. While advanced age represents the strongest risk factor for disease development, it remains...

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Detalles Bibliográficos
Autores principales: Senchuk, Megan M., Van Raamsdonk, Jeremy M., Moore, Darren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925424/
https://www.ncbi.nlm.nih.gov/pubmed/33450392
http://dx.doi.org/10.1016/j.nbd.2021.105267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925424/
https://www.ncbi.nlm.nih.gov/pubmed/33450392
http://dx.doi.org/10.1016/j.nbd.2021.105267

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