Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions

Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) and GITR ligand (GITRL) are members of the tumor necrosis superfamily that play a role in immune cell signaling, activation, and survival. GITR is a therapeutic target for directly activating effector CD4 and CD8 T cells, o...

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Detalles Bibliográficos
Autores principales: Wang, Feng, Chau, Bryant, West, Sean M., Kimberlin, Christopher R., Cao, Fei, Schwarz, Flavio, Aguilar, Barbara, Han, Minhua, Morishige, Winse, Bee, Christine, Dollinger, Gavin, Rajpal, Arvind, Strop, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925557/
https://www.ncbi.nlm.nih.gov/pubmed/33654081
http://dx.doi.org/10.1038/s41467-021-21563-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925557/
https://www.ncbi.nlm.nih.gov/pubmed/33654081
http://dx.doi.org/10.1038/s41467-021-21563-z

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