Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer

We show that treatment with the FDA-approved anti-parasitic drug ivermectin induces immunogenic cancer cell death (ICD) and robust T cell infiltration into breast tumors. As an allosteric modulator of the ATP/P2X4/P2X7 axis which operates in both cancer and immune cells, ivermectin also selectively...

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Detalles Bibliográficos
Autores principales: Draganov, Dobrin, Han, Zhen, Rana, Aamir, Bennett, Nitasha, Irvine, Darrell J., Lee, Peter P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925581/
https://www.ncbi.nlm.nih.gov/pubmed/33654071
http://dx.doi.org/10.1038/s41523-021-00229-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925581/
https://www.ncbi.nlm.nih.gov/pubmed/33654071
http://dx.doi.org/10.1038/s41523-021-00229-5

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