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Stabilization of p18 by deubiquitylase CYLD is pivotal for cell cycle progression and viral replication
p18 is a key negative regulator of cell cycle progression and mediates cell cycle arrest at the G1/S phase. Ubiquitination is the prime mechanism in regulating p18 protein abundance. However, so far no post- translational regulator, especially DUBs, has been identified to regulate the protein stabil...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925679/ https://www.ncbi.nlm.nih.gov/pubmed/33654169 http://dx.doi.org/10.1038/s41698-021-00153-8 |