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TNFRSF13B Diversification Fueled by B Cell Responses to Environmental Challenges—A Hypothesis

B cell differentiation and memory are controlled by the transmembrane activator and CAML interactor (TACI), a receptor encoded by TNFRSF13B. TNFRSF13B mutations are frequently found in common variable immunodeficiency (CVID) and in IgA -deficiency; yet, ~98% of those with mutant TNFRSF13B are health...

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Detalles Bibliográficos
Autores principales: Cascalho, Marilia, Platt, Jeffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925820/
https://www.ncbi.nlm.nih.gov/pubmed/33679786
http://dx.doi.org/10.3389/fimmu.2021.634544