The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetuximab-Resistant Cancer Cells

Ras oncoproteins play a crucial role in the onset, maintenance, and progression of the most common and deadly human cancers. Despite extensive research efforts, only a few mutant-specific Ras inhibitors have been reported. We show that cmp4–previously identified as a water-soluble Ras inhibitor– tar...

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Detalles Bibliográficos
Autores principales: Tisi, Renata, Spinelli, Michela, Palmioli, Alessandro, Airoldi, Cristina, Cazzaniga, Paolo, Besozzi, Daniela, Nobile, Marco S., Mazzoleni, Elisa, Arnhold, Simone, De Gioia, Luca, Grandori, Rita, Peri, Francesco, Vanoni, Marco, Sacco, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925909/
https://www.ncbi.nlm.nih.gov/pubmed/33681292
http://dx.doi.org/10.3389/fmolb.2021.625979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925909/
https://www.ncbi.nlm.nih.gov/pubmed/33681292
http://dx.doi.org/10.3389/fmolb.2021.625979

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