Towards a comprehensive view of 8-oxo-7,8-dihydro-2’-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability

8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), a major product of DNA oxidation, is a pre-mutagenic lesion which is prone to mispair, if left unrepaired, with 2′-deoxyadenosine during DNA replication. While unrepaired or incompletely repaired 8-oxodG has classically been associated with genome insta...

Descripción completa

Detalles Bibliográficos
Autores principales: Gorini, Francesca, Scala, Giovanni, Cooke, Marcus S., Majello, Barbara, Amente, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926032/
https://www.ncbi.nlm.nih.gov/pubmed/33285475
http://dx.doi.org/10.1016/j.dnarep.2020.103027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926032/
https://www.ncbi.nlm.nih.gov/pubmed/33285475
http://dx.doi.org/10.1016/j.dnarep.2020.103027

Ejemplares similares