Cargando…

MITOL promotes cell survival by degrading Parkin during mitophagy

Parkin promotes cell survival by removing damaged mitochondria via mitophagy. However, although some studies have suggested that Parkin induces cell death, the regulatory mechanism underlying the dual role of Parkin remains unknown. Herein, we report that mitochondrial ubiquitin ligase (MITOL/MARCH5...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shiiba, Isshin, Takeda, Keisuke, Nagashima, Shun, Ito, Naoki, Tokuyama, Takeshi, Yamashita, Shun‐Ichi, Kanki, Tomotake, Komatsu, Toru, Urano, Yasuteru, Fujikawa, Yuuta, Inatome, Ryoko, Yanagi, Shigeru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926225/ https://www.ncbi.nlm.nih.gov/pubmed/33565245 http://dx.doi.org/10.15252/embr.201949097

Ejemplares similares

Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases
por: Shiiba, Isshin, et al.
Publicado: (2020)

MITOL prevents ER stress‐induced apoptosis by IRE1α ubiquitylation at ER–mitochondria contact sites
por: Takeda, Keisuke, et al.
Publicado: (2019)

Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation
por: Tokuyama, Takeshi, et al.
Publicado: (2022)

MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress
por: Nagashima, Shun, et al.
Publicado: (2019)

Critical role of CRAG, a splicing variant of centaurin-γ3/AGAP3, in ELK1-dependent SRF activation at PML bodies
por: Nagashima, Shun, et al.
Publicado: (2019)

Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation
por: Takeda, Keisuke, et al.
Publicado: (2021)

Forebrain-specific deficiency of the GTPase CRAG/Centaurin-γ3 leads to immature dentate gyri and hyperactivity in mice
por: Nagashima, Shun, et al.
Publicado: (2021)

Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1
por: Igarashi, Ryoko, et al.
Publicado: (2020)

Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients
por: Tokuyama, Takeshi, et al.
Publicado: (2020)

CAMDI interacts with the human memory-associated protein KIBRA and regulates AMPAR cell surface expression and cognition
por: Fukuda, Toshifumi, et al.
Publicado: (2019)

Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL
por: Koyano, Fumika, et al.
Publicado: (2019)

Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes
por: Koyano, Fumika, et al.
Publicado: (2019)

Development of pathway-oriented screening to identify compounds to control 2-methylglyoxal metabolism in tumor cells
por: Yanagi, Kouichi, et al.
Publicado: (2023)

Oscillation of Cdc20–APC/C–mediated CAMDI stability is critical for cortical neuron migration
por: Okuda, Shohei, et al.
Publicado: (2021)

Association and dissociation between the mitochondrial Far complex and Atg32 regulate mitophagy
por: Innokentev, Aleksei, et al.
Publicado: (2020)

Mechanisms and Physiological Roles of Mitophagy in Yeast
por: Fukuda, Tomoyuki, et al.
Publicado: (2018)

Mitophagy in Yeast: Molecular Mechanism and Regulation
por: Innokentev, Aleksei, et al.
Publicado: (2021)

Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation
por: Varuzhanyan, Grigor, et al.
Publicado: (2021)

Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy
por: Hussain, Mansoor, et al.
Publicado: (2023)

Atg43 tethers isolation membranes to mitochondria to promote starvation-induced mitophagy in fission yeast
por: Fukuda, Tomoyuki, et al.
Publicado: (2020)

The Physiological Role of Mitophagy: New Insights into Phosphorylation Events
por: Hirota, Yuko, et al.
Publicado: (2012)

Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy
por: Yamashita, Shun-ichi, et al.
Publicado: (2016)

Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1
por: Matsushita, Nobuko, et al.
Publicado: (2016)

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
por: Matsuda, Noriyuki, et al.
Publicado: (2010)

Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches
por: Tsefou, Eliona, et al.
Publicado: (2021)

Parkin in cancer: Mitophagy-related/unrelated tasks
por: Eid, Nabil, et al.
Publicado: (2017)

Autophagy Inhibitor LRPPRC Suppresses Mitophagy through Interaction with Mitophagy Initiator Parkin
por: Zou, Jing, et al.
Publicado: (2014)

Phosphorylation of Serine 114 on Atg32 mediates mitophagy
por: Aoki, Yoshimasa, et al.
Publicado: (2011)

RhoA rescues cardiac senescence by regulating Parkin-mediated mitophagy
por: Soh, Joanne Ern Chi, et al.
Publicado: (2023)

Mitophagy and Parkinson's disease: The PINK1–parkin link()
por: Deas, Emma, et al.
Publicado: (2011)

Endosomal Rab cycles regulate Parkin-mediated mitophagy
por: Yamano, Koji, et al.
Publicado: (2018)

Miro proteins prime mitochondria for Parkin translocation and mitophagy
por: Safiulina, Dzhamilja, et al.
Publicado: (2018)

Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria
por: Xiao, Bin, et al.
Publicado: (2017)

MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria
por: Hussain, Mansoor, et al.
Publicado: (2021)

Correction: Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria
por: Xiao, Bin, et al.
Publicado: (2018)

Involvement of Parkin‐mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease‐related sarcopenia
por: Ito, Akihiko, et al.
Publicado: (2022)

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
por: Chan, Nickie C., et al.
Publicado: (2011)

Triggering of Parkin Mitochondrial Translocation in Mitophagy: Implications for Liver Diseases
por: Eid, Nabil, et al.
Publicado: (2016)

Loss of iron triggers PINK1/Parkin-independent mitophagy
por: Allen, George F G, et al.
Publicado: (2013)

Mdm2 enhances ligase activity of parkin and facilitates mitophagy
por: Kook, Seunghyi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_q358qjpqi3f1kkhrcfe568kuie