A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer’s Pathogenesis—And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder

Oxidative stress and increased cytoplasmic calcium are key mediators of the detrimental effects on neuronal function and survival in Alzheimer’s disease (AD). Pathways whereby these perturbations arise, and then prevent dendritic spine formation, promote tau hyperphosphorylation, further amplify amy...

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Detalles Bibliográficos
Autores principales: McCarty, Mark F., DiNicolantonio, James J., Lerner, Aaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926325/
https://www.ncbi.nlm.nih.gov/pubmed/33669995
http://dx.doi.org/10.3390/ijms22042140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926325/
https://www.ncbi.nlm.nih.gov/pubmed/33669995
http://dx.doi.org/10.3390/ijms22042140

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