Differential Effects of STCH and Stress-Inducible Hsp70 on the Stability and Maturation of NKCC2

Mutations in the Na-K-2Cl co-transporter NKCC2 lead to type I Bartter syndrome, a life-threatening kidney disease. We previously showed that export from the ER constitutes the limiting step in NKCC2 maturation and cell surface expression. Yet, the molecular mechanisms involved in this process remain...

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Detalles Bibliográficos
Autores principales: Bakhos-Douaihy, Dalal, Seaayfan, Elie, Demaretz, Sylvie, Komhoff, Martin, Laghmani, Kamel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926544/
https://www.ncbi.nlm.nih.gov/pubmed/33672238
http://dx.doi.org/10.3390/ijms22042207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926544/
https://www.ncbi.nlm.nih.gov/pubmed/33672238
http://dx.doi.org/10.3390/ijms22042207

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