Anti-TNF Alpha Antibody Humira with pH-dependent Binding Characteristics: A constant-pH Molecular Dynamics, Gaussian Accelerated Molecular Dynamics, and In Vitro Study

Humira is a monoclonal antibody that binds to TNF alpha, inactivates TNF alpha receptors, and inhibits inflammation. Neonatal Fc receptors can mediate the transcytosis of Humira–TNF alpha complex structures and process them toward degradation pathways, which reduces the therapeutic effect of Humira....

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Detalles Bibliográficos
Autores principales: Hong, Shih-Ting, Su, Yu-Cheng, Wang, Yu-Jen, Cheng, Tian-Lu, Wang, Yeng-Tseng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926962/
https://www.ncbi.nlm.nih.gov/pubmed/33672169
http://dx.doi.org/10.3390/biom11020334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926962/
https://www.ncbi.nlm.nih.gov/pubmed/33672169
http://dx.doi.org/10.3390/biom11020334

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