A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts

Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause autosomal-dominant Parkinson’s disease (PD) and contribute to sporadic PD. Common genetic variation in LRRK2 modifies susceptibility to immunological disorders including Crohn’s disease and leprosy. Previous studies have reported that...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Tianxia, Ning, Bo, Kong, Lingbo, Dai, Bingling, He, Xiaofei, Thomas, Joseph M., Sawa, Akira, Ross, Christopher A., Smith, Wanli W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926966/
https://www.ncbi.nlm.nih.gov/pubmed/33672296
http://dx.doi.org/10.3390/cells10020480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926966/
https://www.ncbi.nlm.nih.gov/pubmed/33672296
http://dx.doi.org/10.3390/cells10020480

Ejemplares similares