Amorphous Drug–Polymer Salt with High Stability under Tropical Conditions and Fast Dissolution: The Case of Clofazimine and Poly(acrylic acid)

[Image: see text] We report that the stability of amorphous clofazimine (CFZ) against crystallization is vastly improved by salt formation with a polymer without sacrificing dissolution rate. A simple slurry method was used to produce the amorphous salt of CFZ with poly(acrylic acid) (PAA) at 75 wt...

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Detalles Bibliográficos
Autores principales: Gui, Yue, McCann, Erin C., Yao, Xin, Li, Yuhui, Jones, Karen J., Yu, Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927142/
https://www.ncbi.nlm.nih.gov/pubmed/33522821
http://dx.doi.org/10.1021/acs.molpharmaceut.0c01180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927142/
https://www.ncbi.nlm.nih.gov/pubmed/33522821
http://dx.doi.org/10.1021/acs.molpharmaceut.0c01180

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