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Pressure-Driven Mitochondrial Transfer Pipeline Generates Mammalian Cells of Desired Genetic Combinations and Fates

Generating mammalian cells with desired mitochondrial DNA (mtDNA) sequences is enabling for studies of mitochondria, disease modeling, and potential regenerative therapies. MitoPunch, a high-throughput mitochondrial transfer device, produces cells with specific mtDNA-nuclear DNA (nDNA) combinations...

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Detalles Bibliográficos
Autores principales: Patananan, Alexander N., Sercel, Alexander J., Wu, Ting-Hsiang, Ahsan, Fasih M., Torres, Alejandro, Kennedy, Stephanie A.L., Vandiver, Amy, Collier, Amanda J., Mehrabi, Artin, Van Lew, Jon, Zakin, Lise, Rodriguez, Noe, Sixto, Marcos, Tadros, Wael, Lazar, Adam, Sieling, Peter A., Nguyen, Thang L., Dawson, Emma R., Braas, Daniel, Golovato, Justin, Cisneros, Luis, Vaske, Charles, Plath, Kathrin, Rabizadeh, Shahrooz, Niazi, Kayvan R., Chiou, Pei-Yu, Teitell, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927156/
https://www.ncbi.nlm.nih.gov/pubmed/33378680
http://dx.doi.org/10.1016/j.celrep.2020.108562