Structure‐based identification of dual ligands at the A(2A)R and PDE10A with anti‐proliferative effects in lung cancer cell‐lines

Enhanced/prolonged cAMP signalling has been suggested as a suppressor of cancer proliferation. Interestingly, two key modulators that elevate cAMP, the A(2A) receptor (A(2A)R) and phosphodiesterase 10A (PDE10A), are differentially co-expressed in various types of non-small lung cancer (NSCLC) cell-l...

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Detalles Bibliográficos
Autores principales: Kalash, Leen, Winfield, Ian, Safitri, Dewi, Bermudez, Marcel, Carvalho, Sabrina, Glen, Robert, Ladds, Graham, Bender, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927403/
https://www.ncbi.nlm.nih.gov/pubmed/33658076
http://dx.doi.org/10.1186/s13321-021-00492-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927403/
https://www.ncbi.nlm.nih.gov/pubmed/33658076
http://dx.doi.org/10.1186/s13321-021-00492-5

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