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Structure‐based identification of dual ligands at the A(2A)R and PDE10A with anti‐proliferative effects in lung cancer cell‐lines
Enhanced/prolonged cAMP signalling has been suggested as a suppressor of cancer proliferation. Interestingly, two key modulators that elevate cAMP, the A(2A) receptor (A(2A)R) and phosphodiesterase 10A (PDE10A), are differentially co-expressed in various types of non-small lung cancer (NSCLC) cell-l...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927403/ https://www.ncbi.nlm.nih.gov/pubmed/33658076 http://dx.doi.org/10.1186/s13321-021-00492-5 |