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Intact Glucocorticoid Receptor Dimerization Is Deleterious in Trauma-Induced Impaired Fracture Healing
Following severe trauma, fracture healing is impaired because of overwhelming systemic and local inflammation. Glucocorticoids (GCs), acting via the glucocorticoid receptor (GR), influence fracture healing by modulating the trauma-induced immune response. GR dimerization-dependent gene regulation is...
Autores principales: | Hachemi, Yasmine, Rapp, Anna E., Lee, Sooyeon, Dorn, Ann-Kristin, Krüger, Benjamin T., Kaiser, Kathrin, Ignatius, Anita, Tuckermann, Jan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927427/ https://www.ncbi.nlm.nih.gov/pubmed/33679723 http://dx.doi.org/10.3389/fimmu.2020.628287 |
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