RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion

Cdc42-GTP is required for apical domain formation in epithelial cells, where it recruits and activates the Par-6–aPKC polarity complex, but how the activity of Cdc42 itself is restricted apically is unclear. We used sequence analysis and 3D structural modeling to determine which Drosophila GTPase-ac...

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Detalles Bibliográficos
Autores principales: Fic, Weronika, Bastock, Rebecca, Raimondi, Francesco, Los, Erinn, Inoue, Yoshiko, Gallop, Jennifer L., Russell, Robert B., St Johnston, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927664/
https://www.ncbi.nlm.nih.gov/pubmed/33646271
http://dx.doi.org/10.1083/jcb.202009116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927664/
https://www.ncbi.nlm.nih.gov/pubmed/33646271
http://dx.doi.org/10.1083/jcb.202009116

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