Engineered IgG1-Fc Molecules Define Valency Control of Cell Surface Fcγ Receptor Inhibition and Activation in Endosomes

The inhibition of Fcγ receptors (FcγR) is an attractive strategy for treating diseases driven by IgG immune complexes (IC). Previously, we demonstrated that an engineered tri-valent arrangement of IgG1 Fc domains (SIF1) potently inhibited FcγR activation by IC, whereas a penta-valent Fc molecule (Pe...

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Detalles Bibliográficos
Autores principales: Bailey, Elizabeth M., Choudhury, Amit, Vuppula, Harika, Ortiz, Daniel F., Schaeck, John, Manning, Anthony M., Bosques, Carlos J., Hoppe, Adam D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928370/
https://www.ncbi.nlm.nih.gov/pubmed/33679705
http://dx.doi.org/10.3389/fimmu.2020.617767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928370/
https://www.ncbi.nlm.nih.gov/pubmed/33679705
http://dx.doi.org/10.3389/fimmu.2020.617767

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