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Engineered IgG1-Fc Molecules Define Valency Control of Cell Surface Fcγ Receptor Inhibition and Activation in Endosomes
The inhibition of Fcγ receptors (FcγR) is an attractive strategy for treating diseases driven by IgG immune complexes (IC). Previously, we demonstrated that an engineered tri-valent arrangement of IgG1 Fc domains (SIF1) potently inhibited FcγR activation by IC, whereas a penta-valent Fc molecule (Pe...
Autores principales: | Bailey, Elizabeth M., Choudhury, Amit, Vuppula, Harika, Ortiz, Daniel F., Schaeck, John, Manning, Anthony M., Bosques, Carlos J., Hoppe, Adam D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928370/ https://www.ncbi.nlm.nih.gov/pubmed/33679705 http://dx.doi.org/10.3389/fimmu.2020.617767 |
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