Embryonic Expression of Nras(G 12 D) Leads to Embryonic Lethality and Cardiac Defects

Ras proteins control a complex intracellular signaling network. Gain-of-function mutations in RAS genes lead to RASopathy disorders in humans, including Noonan syndrome (NS). NS is the second most common syndromic cause of congenital heart disease. Although conditional expression of the Nras(G12D/)(...

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Detalles Bibliográficos
Autores principales: You, Xiaona, Ryu, Myung-Jeom, Cho, Eunjin, Sang, Yanzhi, Damnernsawad, Alisa, Zhou, Yun, Liu, Yangang, Zhang, Jing, Lee, Youngsook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928391/
https://www.ncbi.nlm.nih.gov/pubmed/33681212
http://dx.doi.org/10.3389/fcell.2021.633661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928391/
https://www.ncbi.nlm.nih.gov/pubmed/33681212
http://dx.doi.org/10.3389/fcell.2021.633661

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