Efficient and flexible Integration of variant characteristics in rare variant association studies using integrated nested Laplace approximation

Rare variants are thought to play an important role in the etiology of complex diseases and may explain a significant fraction of the missing heritability in genetic disease studies. Next-generation sequencing facilitates the association of rare variants in coding or regulatory regions with complex...

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Detalles Bibliográficos
Autores principales: Susak, Hana, Serra-Saurina, Laura, Demidov, German, Rabionet, Raquel, Domènech, Laura, Bosio, Mattia, Muyas, Francesc, Estivill, Xavier, Escaramís, Geòrgia, Ossowski, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928502/
https://www.ncbi.nlm.nih.gov/pubmed/33606672
http://dx.doi.org/10.1371/journal.pcbi.1007784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928502/
https://www.ncbi.nlm.nih.gov/pubmed/33606672
http://dx.doi.org/10.1371/journal.pcbi.1007784

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