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Efficient and flexible Integration of variant characteristics in rare variant association studies using integrated nested Laplace approximation
Rare variants are thought to play an important role in the etiology of complex diseases and may explain a significant fraction of the missing heritability in genetic disease studies. Next-generation sequencing facilitates the association of rare variants in coding or regulatory regions with complex...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928502/ https://www.ncbi.nlm.nih.gov/pubmed/33606672 http://dx.doi.org/10.1371/journal.pcbi.1007784 |