Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport

Human excitatory amino acid transporter 3 (hEAAT3) mediates glutamate uptake in neurons, intestine, and kidney. Here, we report cryo-EM structures of hEAAT3 in several functional states where the transporter is empty, bound to coupled sodium ions only, or fully loaded with three sodium ions, a proto...

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Detalles Bibliográficos
Autores principales: Qiu, Biao, Matthies, Doreen, Fortea, Eva, Yu, Zhiheng, Boudker, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929514/
https://www.ncbi.nlm.nih.gov/pubmed/33658209
http://dx.doi.org/10.1126/sciadv.abf5814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929514/
https://www.ncbi.nlm.nih.gov/pubmed/33658209
http://dx.doi.org/10.1126/sciadv.abf5814

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