Patterns and tempo of PCSK9 pseudogenizations suggest an ancient divergence in mammalian cholesterol homeostasis mechanisms

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a central role in cholesterol homeostasis in humans as a major regulator of LDLR levels. PCSK9 is an intriguing protease in that it does not act by proteolysis but by preventing LDLR recirculation from endosomes to the plasma membrane. This...

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Detalles Bibliográficos
Autores principales: van Asch, Barbara, Teixeira da Costa, Luís Filipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929951/
https://www.ncbi.nlm.nih.gov/pubmed/33515402
http://dx.doi.org/10.1007/s10709-021-00113-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929951/
https://www.ncbi.nlm.nih.gov/pubmed/33515402
http://dx.doi.org/10.1007/s10709-021-00113-x

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