Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation

We previously identified a causal link between a rare patient mutation in DISC1 (disrupted-in-schizophrenia 1) and synaptic deficits in cortical neurons differentiated from isogenic patient-derived induced pluripotent stem cells (iPSCs). Here we find that transcripts related to phosphodiesterase 4 (...

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Detalles Bibliográficos
Autores principales: Kim, Nam-Shik, Wen, Zhexing, Liu, Jing, Zhou, Ying, Guo, Ziyuan, Xu, Chongchong, Lin, Yu-Ting, Yoon, Ki-Jun, Park, Junhyun, Cho, Michelle, Kim, Minji, Wang, Xinyuan, Yu, Huimei, Sakamuru, Srilatha, Christian, Kimberly M., Hsu, Kuei-sen, Xia, Menghang, Li, Weidong, Ross, Christopher A., Margolis, Russell L., Lu, Xin-Yun, Song, Hongjun, Ming, Guo-li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930023/
https://www.ncbi.nlm.nih.gov/pubmed/33658519
http://dx.doi.org/10.1038/s41467-021-21713-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930023/
https://www.ncbi.nlm.nih.gov/pubmed/33658519
http://dx.doi.org/10.1038/s41467-021-21713-3

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