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Lipid regulation of hERG1 channel function

The lipid regulation of mammalian ion channel function has emerged as a fundamental mechanism in the control of electrical signalling and transport specificity in various cell types. In this work, we combine molecular dynamics simulations, mutagenesis, and electrophysiology to provide mechanistic in...

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Detalles Bibliográficos
Autores principales: Miranda, Williams E., Guo, Jiqing, Mesa-Galloso, Haydee, Corradi, Valentina, Lees-Miller, James P., Tieleman, D. Peter, Duff, Henry J., Noskov, Sergei Yu.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930123/
https://www.ncbi.nlm.nih.gov/pubmed/33658490
http://dx.doi.org/10.1038/s41467-021-21681-8