Cargando…
Lipid regulation of hERG1 channel function
The lipid regulation of mammalian ion channel function has emerged as a fundamental mechanism in the control of electrical signalling and transport specificity in various cell types. In this work, we combine molecular dynamics simulations, mutagenesis, and electrophysiology to provide mechanistic in...
Autores principales: | Miranda, Williams E., Guo, Jiqing, Mesa-Galloso, Haydee, Corradi, Valentina, Lees-Miller, James P., Tieleman, D. Peter, Duff, Henry J., Noskov, Sergei Yu. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930123/ https://www.ncbi.nlm.nih.gov/pubmed/33658490 http://dx.doi.org/10.1038/s41467-021-21681-8 |
Ejemplares similares
-
The voltage-sensing domain of a hERG1 mutant is a cation-selective channel
por: Kudaibergenova, Meruyert, et al.
Publicado: (2022) -
Role of the pH in state-dependent blockade of hERG currents
por: Wang, Yibo, et al.
Publicado: (2016) -
Allosteric Coupling Between Drug Binding and the Aromatic Cassette in the Pore Domain of the hERG1 Channel: Implications for a State-Dependent Blockade
por: Kudaibergenova, Meruyert, et al.
Publicado: (2020) -
Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study
por: Perissinotti, Laura L., et al.
Publicado: (2018) -
Structure Driven Design of Novel Human Ether-A-Go-Go-Related-Gene Channel (hERG1) Activators
por: Guo, Jiqing, et al.
Publicado: (2014)