Phosphatase PP2A enhances MCL-1 protein half-life in multiple myeloma cells

Multiple myeloma (MM), a treatable but incurable malignancy, is characterized by the growth of clonal plasma cells in protective niches in the bone marrow. MM cells depend on expression of BCL-2 family proteins, in particular MCL-1, for survival. The regulation of MCL-1 is complex and cell type-depe...

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Detalles Bibliográficos
Autores principales: Slomp, Anne, Moesbergen, Laura M., Eldering, Eric, Kersten, Marie José, Minnema, Monique C., Peperzak, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930201/
https://www.ncbi.nlm.nih.gov/pubmed/33658484
http://dx.doi.org/10.1038/s41419-020-03351-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930201/
https://www.ncbi.nlm.nih.gov/pubmed/33658484
http://dx.doi.org/10.1038/s41419-020-03351-7

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