Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors

In this work, we are reporting that “Shock and Kill”, a therapeutic approach designed to eliminate latent HIV from cell reservoirs, is extrapolatable to cancer therapy. This is based on the observation that malignant cells express a spectrum of human endogenous retroviral elements (HERVs) which can...

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Detalles Bibliográficos
Autores principales: Díaz-Carballo, David, Saka, Sahitya, Acikelli, Ali H., Homp, Ekaterina, Erwes, Julia, Demmig, Rebecca, Klein, Jacqueline, Schröer, Katrin, Malak, Sascha, D’Souza, Flevy, Noa-Bolaño, Adrien, Menze, Saskia, Pano, Emilio, Andrioff, Swetlana, Teipel, Marc, Dammann, Philip, Klein, Diana, Nasreen, Amber, Tannapfel, Andrea, Grandi, Nicole, Tramontano, Enzo, Ochsenfarth, Crista, Strumberg, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930250/
https://www.ncbi.nlm.nih.gov/pubmed/33658617
http://dx.doi.org/10.1038/s42003-021-01800-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930250/
https://www.ncbi.nlm.nih.gov/pubmed/33658617
http://dx.doi.org/10.1038/s42003-021-01800-3

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