Targeted Reducing of Tauopathy Alleviates Epileptic Seizures and Spatial Memory Impairment in an Optogenetically Inducible Mouse Model of Epilepsy

Intracellular deposition of hyperphosphorylated tau has been reported in the brain of epilepsy patients, but its contribution to epileptic seizures and the association with spatial cognitive functions remain unclear. Here, we found that repeated optogenetic stimulation of the excitatory neurons in v...

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Detalles Bibliográficos
Autores principales: Gao, Yang, Zheng, Jie, Jiang, Tao, Pi, Guilin, Sun, Fei, Xiong, Rui, Wang, Weijin, Wu, Dongqin, Li, Shihong, Lei, Huiyang, Yu, Huiling, Zhou, Qiuzhi, Yang, Ying, Zhang, Huaqiu, Wang, Jian-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930339/
https://www.ncbi.nlm.nih.gov/pubmed/33681188
http://dx.doi.org/10.3389/fcell.2020.633725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930339/
https://www.ncbi.nlm.nih.gov/pubmed/33681188
http://dx.doi.org/10.3389/fcell.2020.633725

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