Comparison of the Inhibitory Binding Modes Between the Planar Fascaplysin and Its Nonplanar Tetrahydro-β-carboline Analogs in CDK4

Fascaplysin is a natural marine product originating from sponges, attracting widespread attention due to its potential inhibitory activities against CDK4. However, its clinical application has been largely limited because of serious adverse effects caused by planar skeleton. To reduce the serious ad...

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Detalles Bibliográficos
Autores principales: Liang, Yan, Quan, Huili, Bu, Tong, Li, Xuedong, Liu, Xingang, Wang, Songsong, He, Dian, Jia, Qingzhong, Zhang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930575/
https://www.ncbi.nlm.nih.gov/pubmed/33681142
http://dx.doi.org/10.3389/fchem.2021.614154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930575/
https://www.ncbi.nlm.nih.gov/pubmed/33681142
http://dx.doi.org/10.3389/fchem.2021.614154

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