Cargando…

Comparison of the Inhibitory Binding Modes Between the Planar Fascaplysin and Its Nonplanar Tetrahydro-β-carboline Analogs in CDK4

Fascaplysin is a natural marine product originating from sponges, attracting widespread attention due to its potential inhibitory activities against CDK4. However, its clinical application has been largely limited because of serious adverse effects caused by planar skeleton. To reduce the serious ad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liang, Yan, Quan, Huili, Bu, Tong, Li, Xuedong, Liu, Xingang, Wang, Songsong, He, Dian, Jia, Qingzhong, Zhang, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930575/ https://www.ncbi.nlm.nih.gov/pubmed/33681142 http://dx.doi.org/10.3389/fchem.2021.614154

Ejemplares similares

Exploring planar and nonplanar siligraphene: a first-principles study
por: Tang, Xudong, et al.
Publicado: (2019)

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors
por: Abadi, Ashraf H., et al.
Publicado: (2011)

Synthesis and Antibacterial Study of Novel Harmine Derivatives and Tetrahydro-β-Carboline Derivatives In Vitro
por: Liang, Yan, et al.
Publicado: (2022)

FASCAPLYSIN as a Specific Inhibitor for CDK4: Insights from Molecular Modelling
por: Shafiq, Muhammad Imtiaz, et al.
Publicado: (2012)

Synthesis, Molecular Docking and Antiplasmodial Activities of New Tetrahydro-β-Carbolines
por: Jaromin, Anna, et al.
Publicado: (2021)

Synthesis of tetrahydro-β-carbolines from 2-indolylmethyl azides and propargylic alcohols
por: Yin, Haiting, et al.
Publicado: (2021)

Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of Plant Pathogenic Fungi
por: Buaban, Koonchira, et al.
Publicado: (2021)

Synthesis and biological activity of N-substituted-tetrahydro-γ-carbolines containing peptide residues
por: Sokolova, Nadezhda V, et al.
Publicado: (2014)

Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction
por: Xu, Shi-Ming, et al.
Publicado: (2019)

Discovery of Novel Tetrahydro-β-carboline Containing Aminopeptidase N Inhibitors as Cancer Chemosensitizers
por: Xing, Xiaoyan, et al.
Publicado: (2022)

Electrochemical oxidative rearrangement of tetrahydro-β-carbolines in a zero-gap flow cell
por: Zheng, Yiting, et al.
Publicado: (2022)

Microfabrication of Nonplanar Polymeric Microfluidics
por: Chen, Pin-Chuan, et al.
Publicado: (2018)

Synthesis of 1-Substituted Carbazolyl-1,2,3,4-tetrahydro- and Carbazolyl-3,4-dihydro-β-carboline Analogs as Potential Antitumor Agents
por: Shen, Ya-Ching, et al.
Publicado: (2011)

Theoretical Insight Into the Ultralong Room-Temperature Phosphorescence of Nonplanar Aromatic Hydrocarbon
por: Qin, Ke, et al.
Publicado: (2021)

Asymmetric Synthesis of (R)‐1‐Alkyl‐Substituted Tetrahydro‐ß‐carbolines Catalyzed by Strictosidine Synthases
por: Pressnitz, Desiree, et al.
Publicado: (2018)

Implications of nonplanar dual conformal symmetry
por: Chicherin, D., et al.
Publicado: (2018)

Synergistic cytotoxicity of the CDK4 inhibitor Fascaplysin in combination with EGFR inhibitor Afatinib against Non-small Cell Lung Cancer
por: Plangger, Adelina, et al.
Publicado: (2021)

Pharmacological Importance of Optically Active Tetrahydro-β-carbolines and Synthetic Approaches to Create the C1 Stereocenter
por: Laine, Aino E., et al.
Publicado: (2014)

Carbazole and tetrahydro-carboline derivatives as dopamine D(3) receptor antagonists with the multiple antipsychotic-like properties
por: Li, Zhongtang, et al.
Publicado: (2023)

Strain and the optoelectronic properties of nonplanar phosphorene monolayers
por: Mehboudi, Mehrshad, et al.
Publicado: (2015)

On-Surface Synthesis of a Nonplanar Porous Nanographene
por: Xu, Kun, et al.
Publicado: (2019)

Synthesis of Nonplanar Graphene Nanoribbon with Fjord Edges
por: Yao, Xuelin, et al.
Publicado: (2021)

Nonplanar Spray-Coated Perovskite Solar Cells
por: Thornber, Timothy, et al.
Publicado: (2022)

Nonplanar 3D Printing of Bifurcating Forms
por: Mitropoulou, Ioanna, et al.
Publicado: (2022)

The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure
por: Airaghi, Francesco, et al.
Publicado: (2013)

Enzymatic Strategy for the Resolution of New 1‐Hydroxymethyl Tetrahydro‐β‐carboline Derivatives in Batch and Continuous‐Flow Systems
por: Megyesi, Rita, et al.
Publicado: (2016)

Ingenine F: A New Cytotoxic Tetrahydro Carboline Alkaloid from the Indonesian Marine Sponge Acanthostrongylophora ingens
por: Ibrahim, Sabrin, et al.
Publicado: (2018)

A facile and efficient method for the synthesis of crystalline tetrahydro-β-carbolines via the Pictet-Spengler reaction in water
por: Byeon, Hong-Ju, et al.
Publicado: (2020)

Diastereoselective approach to rationally design tetrahydro-β-carboline–isatin conjugates as potential SERMs against breast cancer
por: Sharma, Bharvi, et al.
Publicado: (2019)

TCCA-mediated oxidative rearrangement of tetrahydro-β-carbolines: facile access to spirooxindoles and the total synthesis of (±)-coerulescine and (±)-horsfiline
por: Sathish, Manda, et al.
Publicado: (2021)

Structure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors
por: Elhady, Ahmed K., et al.
Publicado: (2015)

Oxidative Asymmetric Formal Aza-Diels–Alder Reactions of Tetrahydro-β-carboline with Enones in the Synthesis of Indoloquinolizidine-2-ones
por: Wu, Xiang, et al.
Publicado: (2018)

Design, Synthesis, Antiproliferative Evaluation, and Molecular Docking Studies of N-(3-Hydroxyindole)-Appended β-Carbolines/Tetrahydro-β-Carbolines Targeting Triple-Negative and Non-Triple-Negative Breast Cancer
por: Sharma, Bharvi, et al.
Publicado: (2020)

Nonplanar Anomalies in Noncommutative Theories and the Green-Schwarz Mechanism
por: Armoni, Adi, et al.
Publicado: (2002)

Elucidating Atropisomerism in Nonplanar Porphyrins with Tunable Supramolecular Complexes
por: Norvaiša, Karolis, et al.
Publicado: (2020)

The Marine-Derived Kinase Inhibitor Fascaplysin Exerts Anti-Thrombotic Activity
por: Ampofo, Emmanuel, et al.
Publicado: (2015)

Fascaplysin Sensitizes Anti-Cancer Effects of Drugs Targeting AKT and AMPK
por: Oh, Taek-In, et al.
Publicado: (2017)

Adsorption Behavior of Nonplanar Phthalocyanines: Competition of Different Adsorption Conformations
por: Wruss, Elisabeth, et al.
Publicado: (2016)

Strategic Synthesis of ‘Picket Fence’ Porphyrins Based on Nonplanar Macrocycles
por: Norvaiša, Karolis, et al.
Publicado: (2021)

Size-dependent properties and unusual reactivity of novel nonplanar heterocycloarenes
por: Zhu, Jiangyu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qivriq9oekdu9d6d5grku3gibm