LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy

BACKGROUND: Chronic inflammation and residual HIV transcription persist in people living with HIV (PLWH) receiving antiretroviral therapy (ART), thus increasing the risk of developing non-AIDS co-morbidities. The mechanistic target of rapamycin (mTOR) is a key regulator of cellular metabolism and HI...

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Detalles Bibliográficos
Autores principales: Planas, Delphine, Pagliuzza, Amélie, Ponte, Rosalie, Fert, Augustine, Marchand, Laurence Raymond, Massanella, Marta, Gosselin, Annie, Mehraj, Vikram, Dupuy, Franck P, Isnard, Stéphane, Goulet, Jean-Philippe, Lesage, Sylvie, Cohen, Eric A., Ghali, Mager Peter, Angel, Jonathan B., Chomont, Nicolas, Routy, Jean-Pierre, Ancuta, Petronela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930590/
https://www.ncbi.nlm.nih.gov/pubmed/33662832
http://dx.doi.org/10.1016/j.ebiom.2021.103270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930590/
https://www.ncbi.nlm.nih.gov/pubmed/33662832
http://dx.doi.org/10.1016/j.ebiom.2021.103270

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